A remote controlled drug delivery capsule for use in absorption studies has been developed by a UK company. The new technology, called the Enterion capsule. The Enterion capsule has been developed to investigate the absorption of The technology has been in routine use for several years and. formulations and delivery technologies that target the right place in the GI tract. delivered to specific sites via the Enterion capsule. The drugs.
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The Pharmaceutical Journal Vol No p May 27, Clinical Remote control capsule for absorption studies A remote controlled drug delivery capsule for use in absorption studies has been developed by a UK company. The new technology, called the Enterion capsule, is being used by Pharmaceutical Profiles, an early phase development company.
It was developed by Phaeton Research, a sister company to Pharmaceutical Profiles. The capsule is designed to release drug at an exact target site in the gastrointestinal tract. Researchers can then measure the extent to which the drug is absorbed from different regions of the GI tract. The capsule is activated by a radiofrequency signal, which releases a spring-controlled piston and leads to release of the capsule contents see Figure.
The location of the capsule within the GI tract is tracked using gamma scintigraphy while the presence of a radiolabel within the drug reservoir allows visualisation of the drug in the GI tract following activation.
The empty capsule is excreted. Dr Ian Wilding chief executive, Pharmaceutical Profiles said recently that many candidate drug molecules currently being developed had complex chemistry, poor solubility and limited permeability, which led to problems of delivering the drugs effectively to patients.
Magnetically Actuated Soft Capsule With the Multimodal Drug Release Function
Traditional studies to measure absorption profiles tended to be carried out on products that were already formulated and the chosen formulation could turn out not to be ideal. With the new technology, which could test particulates and liquids, decisions on optimal drug delivery technology, or on whether the oral route was perhaps not suitable after all, could now be taken before too much time had been spent on formulation development.
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Remote control capsule for absorption studies
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Latest Role of dual capsulw triple fixed-dose combination inhalers in the treatment of chronic obstructive pulmonary disease 5 NOV Latest Celebrating a year of career highlights 12 DEC Latest views Mark Lyonette: Remote control capsule for absorption studies. A radiofrequency signal releases a spring-controlled piston and enteriob movement of the piston barrel initiates rapid release of technokogy contents into the target area.
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A remote controlled drug delivery capsule for use in absorption studies has been developed by a UK company.