Cemento-ossifying fibroma is classified as an osteogenic tumor, defined as a well -differentiated tumor, occasionally encapsulated, comprising fibrous tissue. Abstract. Introduction: Cemento-ossifying fibroma is a benign fibro-osseous maxillary tumor belonging to the same category as fibrous dysplasia and. Background: Cemento-Ossifying Fibroma (COF) is considered by most as relatively rare, benign, non-odontogenic neoplasm of the jaw bones and other.

Author: Shakaktilar Vudorr
Country: Kosovo
Language: English (Spanish)
Genre: Art
Published (Last): 12 September 2012
Pages: 398
PDF File Size: 2.97 Mb
ePub File Size: 14.28 Mb
ISBN: 755-4-12001-779-3
Downloads: 27554
Price: Free* [*Free Regsitration Required]
Uploader: Mezizilkree

To receive news and publication updates for Case Reports in Dentistry, enter your email address in the box below. An erratum for this article has been published. To fkbroma the erratum, please click here. This is an open access article distributed under the Creative Commons Attribution License fkbroma, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

The concept of fibroosseous lesions of bone has evolved over the last several decades and now includes two major entities: Peripheral cemento-ossifying ossifuing is a relatively rare tumour classified between fibroosseous lesions.

The cemento-ossifying fibroma is a central neoplasm of bone as well as periodontium which has caused considerable controversy because of confusion regarding terminology and the criteria for its diagnosis. The cemento-ossifying fibroma is odontogenic in origin, whereas ossifying fibroma is of bony origin. Lesions histologically similar to peripheral ossifying fibroma have been given various names in existing literature.

Therefore, we present and discuss in this paper a series ossifyinng cases of peripheral cemento-ossifying fibroma emphasizing the differential diagnosis.

Benign fibroosseous lesions of the jaws present problems in diagnosis and classification. The WHO classification groups under a single designation cemento-ossifying fibroma two histologic types cementifying fibroma and ossifying fibroma that may be clinically and radiographically undistinguishable [ 1 ].

Cemento-ossifying fibroma is a relative rare lesion considered as an osteogenic tumor nonodontogenic with variable expressiveness. It is defined as a well-demarcated and occasionally encapsulated lesion consisting of fibrous tissue containing variable amounts of mineralized material resembling bone ossifying fibromacementum cementifying fibromaor both [ 23 ].

Peripheral cemento-ossifying fibroma PCOF accounts for 3. The cemenot of this tumor is uncertain. Due to their clinical and histopathological similarities, some PCOFs are believed to develop fibrous maturation and subsequent calcification.

PCOF is frequently associated with irritant agents such as calculus, bacterial plaque, orthodontic appliances, ill adapted crowns, and irregular restorations. The mineralized product probably originates from periosteal cells or from the periodontal ligament [ 6 ]. PCOF affects both genders, but a higher predilection for females has been reported in the literature [ 4 ].

It may occur at any range, but exhibits a peak incidence between the second [ 8 ] and third decades [ 7 ]. However, Neville et al. Clinically, PCOF manifests as a pediculate or sessile nodular mass, which usually originates in the interdental papilla. Its color is similar to that of the mucosa unless the lesion is ulcerated. A potential of tooth migration PCOF has been reported [ 6 ]. Hence, the purpose of this paper is to present a series of cases of PCOF lesions and emphasize the importance of discussion of the reasonable differential diagnosis with the patient.

Lesion started as a small papule approximately 1 year earlier. According to the patient, there was no bleeding and pain except difficulty in mastication. Examination revealed approximately pedunculated nontender, firm, pinkish red growth present on the buccal gingival in relation to maxillary right canine to 1st molar.

The lesion extended up to the level of occlusal plane and revealed indentations made by the occluding mandibular premolar. The surface of the occlusal plane was pinkish red in color Figure 1. According to the patient, the reddish purple lump has been present for approximately 6 months and the lump was interfering with his bite and felt uncomfortable. Occasionally bleeding occurred when he brushed his teeth.

Clinical examination revealed erythematous interdental papilla in relation to maxillary central incisors 11,12 visible from facial aspect with no evidence of lesion palatally. The lesion appeared exophytic and nodular with irregular surface.


It was slightly pedunculated with what appeared to be a broad-based attachment. The lesion was neither fluctuant nor did it blanch on pressure, but had a rubbery consistency. It was tender Figure 2.

Ossofying year-old male patient was referred by his general dental practitioner for gingival swelling in relation 15 to 16 region. The past dental history revealed presence of swelling since last one and half year duration.

On examination, the associated soft tissue was slightly swollen but there was no ulceration, on palpation the ossitying was soft rubbery in consistency, but no tenderness. The lesion was well demarcated and pedunculated measuring approximately Figure 3.

The patient was apparently asymptomatic 18 months back when he developed a small swelling in the mandibular anterior labial region in 31, 41 which gradually increased in size.

On examination, a uniform rounded swelling was present in mandibular anterior region due to which the patient could not chew the food. The size of vibroma lesion was and the shape was ovoid.

Cemento-ossifying fibroma

The overlying mucosa was pinkish in color and firm in consistency. The texture was smooth.

There was no compressibility or depressibility Figure 4. Differential diagnosis consisted of irritational fibroma, pyogenic granuloma, peripheral giant cell granuloma, peripheral cemento-ossifying fibroma. A confirmatory diagnosis of peripheral cemento-ossifying fibroma is made by histopathologic evaluation of biopsy specimens. The following features were cemfnto during microscopic examination: Peripheral ossifying fibroma is thought to ossifyibg either reactive or neoplastic in nature.

Considerable confusion has prevailed in the nomenclature of peripheral ossifying fibroma with various synonyms being used, such as peripheral cementifying fibroma, ossifying fibroepithelial polyp, peripheral fibroma with osteogenesis, peripheral fibroma with cementogenesis, peripheral fibroma with calcification, calcifying or ossifying fibroma epulis, and calcifying fibroblastic granuloma [ 10 ].

Ossifying fibromas elaborate bone, cementum and spheroidal calcifications, which has given rise to various terms for these benign ceemnto neoplasms. When bone and cementum-like tissues are observed, the lesions have been referred to as cemento-ossifying fibroma [ 11 ]. Cementifying fibromas may be clinically and radiographically impossible to separate from ossifying fibromas [ 12 ].

There was a problem providing the content you requested

An attempt has been made by Endo et al. The term cemento-ossifying has been referred to as outdated and scientifically inaccurate [ 13 ] because the clinical presentation and histopathology of cemento-ossifying fibroma are the same in areas where there is no cementum, such as the skull, femur, and tibia. These are all ossifying fibromas; those that happen to occur in the jaws should not be termed cement ossifying fibromas merely because of the presence of teeth.

Moreover, there is no histologic or biochemical difference between cementum and bone. Cemento-ossifying fibroma is the term given mainly due to presence of dysmorphic round basophilic bone particles within ossifying fibroma, which have arbitrarily been called cementicles. However, these so-called cementicles are not from cementum but instead represent a dysmorphic product of this tumour analogous to the keratin pearls, which are a dysmorphic product of squamous cell carcinoma [ 13 ]. Though the etiopathogenesis of peripheral ossifying fibroma is uncertain, an origin from cells of periodontal ligament has been suggested [ 10 ].

The reasons for considering periodontal ligament origin for peripheral ossifying fibroma include exclusive occurrence of peripheral ossifying fibroma in the gingiva interdental papillathe proximity of gingiva to the periodontal ligament, and the presence of oxytalan fibres within the mineralized matrix of some lesions [ 10 ].

Excessive proliferation of mature fibrous connective tissue is a response to gingival injury, gingival irritation, subgingival calculus, or a foreign body in the gingival sulcus. Chronic irritation of the periosteal and periodontal membrane causes metaplasia of the connective tissue and resultant initiation of formation of bone or dystrophic calcification. It has been suggested that the lesion may be caused by fibrosis of the granulation tissue [ 14 ].

Cemento-ossifying fibroma More C, Thakkar K, Asrani M – Indian J Dent Res

Lesions involving the gingival soft tissues are rare compared to the lesions appearing within bone [ 12 ossiyfing. Mesquita RA found higher numbers of argyrophilic nucleolar organizer regions AgNORs and proliferating cell nuclear antigen- PCNA- positive cells in ossifying fibroma than in peripheral ossifying fibroma, cement higher proliferative activity ossifyint ossifying fibroma [ 15 ].


X-ray diffraction analysis indicated that the mineral phase of both central and peripheral tissues consists of apatite crystals and that the crystallinity of the apatites might improve progressively with the development of the lesion, possibly to the same degree as that of bone apatite [ 16 ]. Peripheral ossifying fibroma tends to occur in the 2nd and 3rd decades of life, with peak prevalence between the ages of 10 and Eversole and Rovin [ 17 ] stated the similar sex and site predilection of pyogenic granuloma.

Gardner [ 18 ] stated that peripheral ossifying fibroma, cellular fibbroma tissue is so characteristic that a histologic diagnosis can be made with confidence, regardless of the presence fihroma absence of calcification. Buchner and Hansen [ 19 ] hypothesized that early POF presents as ulcerated nodules ossifyin little calcification, allowing easy misdiagnosis as a pyogenic granuloma.

Although it is also important to maintain a high index of suspicion, discussion dibroma family members should be tactful to prevent undue distress during the waiting period between differential diagnosis and definitive histopathologic diagnosis.

Because the clinical appearance of these various lesions can be remarkably similar, classification is based on their distinct histologic differences.

Histologically, the PODF has been defined as a fibroblastic neoplasm containing odontogenic epithelium [ 20 ]. Despite a preponderance of the literature supporting differentiation, some authors continue to argue that the POF or peripheral cemento-ossifying fibroma is the peripheral counterpart of the central cemento-ossifying fibroma [ 21 ]. The POF, as discovered in this case, is a focal, reactive, nonneoplastic tumour-like growth of soft tissue often arising from the interdental papilla [ 19 ].

Das [ 8 ] obtained similar results, with 1. POFs are believed to ossifjing from gingival fibers of the periodontal ligament as hyperplastic growth of tissue that is unique to the gingival mucosa [ 1718 ]. This hypothesis is based on the fact that POFs arise exclusively on the gingiva, the subsequent proximity of the gingiva to the periodontal ligament, and the inverse correlation between age csmento of patients presenting with POF and the number of missing teeth with associated periodontal ligament [ 20 ].

The POF lesion is generally small and does not require imaging beyond radiographs [ 18 ]. Treatment consists of conservative surgical excision [ 20 ] and scaling of adjacent teeth [ 18 ]. Therefore, regular followup is required.

Case Reports in Dentistry

Although peripheral ossifying fibroma is benign, reactive lesion, the recurrence rate is fairly high. Therefore, the patients are still under follow-up period. POF is a slowly progressing lesion, the growth of which is generally limited. Many cases will progress for long periods before patients seek treatment because of the lack of symptoms associated with the lesion.

A slowly growing pink soft-tissue nodule in the anterior maxilla of an adolescent fibrroma raise suspicion of a POF.

Discussion of the differential diagnosis should be done tactfully to prevent unnecessary distress to the patient and family.

In the current case, the family experienced distress related to the suggestion of squamous cell carcinoma before referral for treatment and definitive diagnosis.

Treatment consists of surgical excision, including the periosteum and scaling of adjacent teeth. Case Reports in Dentistry. Indexed in Web of Science. Subscribe to Table of Contents Alerts. Table of Contents Alerts. Abstract The concept of fibroosseous lesions of bone has evolved over the last several decades and now includes two major entities: Introduction Benign fibroosseous lesions of the jaws present problems in diagnosis and classification.